How Long Does Oxycodone Stay in Your System?
Oxycodone is a prescription opioid used for moderate to severe pain relief. Because of its potency and potential for dependence, many people want to know how long oxycodone stays in the body and how long it can be detected on a drug test. Detection timelines vary based on test type, dosage, metabolism, and frequency of use.
On average, oxycodone stays in the system for 1 to 4 days. Chronic or heavy use may result in longer detection windows depending on the drug test.
Oxycodone Detection Times by Test Type
Below are typical detection windows for oxycodone and its metabolites:
| Test Type | Detection Window |
|---|---|
| Urine | 1 to 4 days |
| Blood | Up to 24 hours |
| Saliva | 1 to 2 days |
| Hair | Up to 90 days |
Many opioid drug screens test for metabolites such as oxymorphone and noroxycodone, which may remain longer in the system than oxycodone itself.
Oxycodone Half Life
Oxycodone has a half life of approximately 3 to 5 hours, meaning half of the drug leaves the bloodstream within that timeframe. Extended release formulations may have a longer half life and remain detectable longer.
- Immediate release oxycodone: short half life, rapid onset
- Extended release oxycodone (OxyContin): detectable for longer periods
Factors That Affect How Long Oxycodone Stays in Your System
- Frequency of use – longer detection times with repeated use
- Dosage
- Formulation (IR vs ER)
- Age and metabolism
- Liver and kidney health
- Hydration levels
- Body fat percentage
How Long Do the Effects of Oxycodone Last?
Oxycodone’s effects vary based on the formulation:
- Immediate release: effects typically last 3 to 6 hours
- Extended release: effects may last 12 hours or longer
Because oxycodone is a central nervous system depressant, risks include slowed breathing, drowsiness, confusion, and impaired coordination.
Risks of Oxycodone Misuse
Although prescribed legally, oxycodone has a high potential for dependence and misuse. Extended or high dose use increases the risk of overdose and addiction.
Potential risks include:
- Respiratory depression
- Dependence and withdrawal
- Constipation
- Impaired coordination
- Increased tolerance
- Overdose
Many individuals struggling with opioid use may not realize how quickly tolerance and dependence can develop.
Signs of Oxycodone Misuse
- Using more than prescribed
- Cravings or preoccupation with the medication
- Taking oxycodone for reasons other than pain
- Changes in mood or behavior
- Doctor shopping or requesting early refills
- Withdrawal symptoms when not using
Related resources:
Treatment for Oxycodone Addiction
If oxycodone use is interfering with your life, health, or relationships, treatment can help. At The Heights Treatment in Houston, we provide structured programs designed for adults seeking recovery from opioid dependence.
Our treatment options include:
- Partial Hospitalization Program (PHP)
- Intensive Outpatient Program (IOP)
- Psychiatric care and medication management
- Cognitive Behavioral Therapy (CBT)
- Dialectical Behavior Therapy (DBT)
- Dual diagnosis treatment
If you or your loved one needs help, call (832) 979 3625 or visit The Heights Treatment to schedule a confidential assessment.
Sources
- National Institute on Drug Abuse — Prescription Opioids
- NCBI — Oxycodone Pharmacology
- Centers for Disease Control and Prevention
