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Medically reviewed by
On October 30, 2023
Updated: January 20, 2026

How Long Does Codeine Stay in Your System?

Codeine is a prescription opioid used to treat mild to moderate pain and suppress cough. Because it is an opioid, repeated use can lead to tolerance, dependence, and withdrawal.

Codeine is typically detectable for 2 to 4 days in urine, up to 36 hours in saliva, and up to 90 days in hair tests.

Codeine Detection Times

  • Urine: 2 to 4 days (longer in chronic use)
  • Saliva: Up to 36 hours
  • Hair: Up to 90 days
  • Blood: Up to 24 hours

Codeine Half-Life

The half-life of codeine ranges from 1 to 2 hours. It is metabolized in the liver into morphine and other metabolites.

Risks of Codeine Misuse

  • Tolerance
  • Dependence
  • Withdrawal symptoms
  • Respiratory depression
  • Overdose risk (especially with alcohol or benzodiazepines)

Because codeine affects the opioid receptors in the brain, withdrawal symptoms may include nausea, sweating, anxiety, muscle aches, and cravings.

Learn more about opioid withdrawal symptoms.

Treatment for Codeine Addiction in Houston

If codeine use has become difficult to control, structured treatment can help. Opioid misuse often overlaps with anxiety, depression, or trauma-related symptoms.

Call (832) 979-3625 or contact our admissions team for confidential support.


Amanda Stevens, BS

Amanda Stevens is a highly respected figure in the field of medical content writing, with a specific focus on eating disorders and addiction treatment. Amanda earned a Bachelor of Science degree in Social Work from Purdue University, graduating Magna Cum Laude, which serves as a strong educational foundation for her contributions.